Dodoth pastoralists and Ik farmers lived in the area before it was gazetted as a game reserve by the British colonial government in 1958. The purpose was both to protect the animals from hunting and to prevent further clearing of bush for tsetse fly control. The game reserve was converted into the Kidepo Valley National Park in 1962.
The first Chief Warden of the National Park was Ian Ross, a Briton. In 1972 Paul Ssali, a Ugandan, replaced him. Their handover and training was the subject of the 1974 American documentary film, “The Wild and the Brave.”